A flow-through cell dissolution testing system is a type of dissolution tester that uses a flow-through cell to hold the dosage form being tested. The dissolution medium is pumped through the cell at a controlled flow rate and temperature. The eluate is filtered at the top of the cell and then collected either manually or by a sample collector.

Flow-through cell dissolution testing systems are highly versatile and can be used to test a wide variety of dosage forms, including tablets, capsules, powders, suppositories, and implants. They are also well-suited for testing extended-release and modified-release dosage forms.

Here are some of the key components of a flow-through cell dissolution testing system:

  • Dissolution medium reservoir: A container that holds the dissolution medium.
  • Pump: A pump that forces the dissolution medium through the flow-through cell.
  • Flow-through cell: A cell that holds the dosage form being tested. The cell is typically made of glass or stainless steel and has a filter at the top to collect the eluate.
  • Water bath: A water bath that controls the temperature of the dissolution medium in the flow-through cell.
  • Sample collector: A device that collects the eluate from the flow-through cell at predetermined intervals.

Flow-through cell dissolution testing systems are used in a variety of settings, including pharmaceutical manufacturing, quality control laboratories, and research institutions. They are an essential tool for ensuring the quality and performance of pharmaceutical products.

Here are some of the advantages of using a flow-through cell dissolution testing system:

  • Versatility: Flow-through cell dissolution testing systems can be used to test a wide variety of dosage forms.
  • Accuracy: Flow-through cell dissolution testing systems are very accurate and reproducible.
  • Flexibility: Flow-through cell dissolution testing systems offer a great deal of flexibility in terms of test parameters, such as flow rate, temperature, and sample collection intervals.
  • Automation: Flow-through cell dissolution testing systems can be automated, which can save time and improve efficiency.

Overall, flow-through cell dissolution testing systems are a valuable tool for pharmaceutical manufacturing and quality control. They offer a number of advantages over other types of dissolution testers, including versatility, accuracy, flexibility, and automation.

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8000-1 CE 7smart Offline Sotax Flow-through Cell Dissolution Testing System to Automatically Collect Samples

Sotax CE 7smart Offline Flow-through cell dissolution testing system to automatically collect samples.
  • COLLECT – Collect dissolution testing samples in tubes or vials
  • CONTROLLED – Controlled hydrodynamics
  • OPEN – Open loop configuration with infinite sink conditions, automated pH changes
  • CLOSED – Closed loop configuration with fixed volumes (15 - 4000 mL) for compendial low-volume dissolution
  • IVIVC – Simplified in-vitro / in-vivo correlation with open loop configuration
  • ADAPT – Test APIs, oral, topical and parenteral dosage forms reproducibly
  • CLEAN – Automated cleaning procedure